Liposarcoma Treatment: Surgery, Radiation, Chemotherapy – Verywell Health

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Liposarcoma Treatment: Surgery, Radiation, Chemotherapy – Verywell Health

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Yvelette Stines, MS, MEd, is an author, writer, and communications specialist specializing in health and wellness.
Liposarcoma is a rare cancer that starts in the fat cells, most commonly occurring in the legs, abdomen, or arms. The tumor is usually painless and grows slowly. In some cases, though, it grows rapidly, which can cause the tumor to put pressure on the nearby organs and tissues.
There are several treatment options available for this type of cancer. Treatment options depend on the size and location of the tumor and whether the cancer has spread. This article will review the most common treatments for liposarcoma.
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There are no home remedies to effectively treat liposarcoma.
Some experts recommend adopting certain health-promoting lifestyle habits during treatment, such as eating plenty of nutrient-rich foods (such as lean protein, fruits, and vegetables), limiting processed foods and sugar, and eliminating alcohol and tobacco. These efforts can help keep your strength and energy up and improve your ability to tolerate harsh side effects from treatment.
Surgery is generally the first-line treatment for liposarcoma that has not spread to other areas of the body. The two main types of surgery, depending on the size and location of the tumor are:
In very rare cases, if the tumor is very large or has spread, and it is affecting a limb, amputation may be necessary.

Chemotherapy is medication that kills cancer cells throughout the body. It can be given in the form of a pill or through an intravenous (IV, within a vein) infusion.
This treatment may be used before surgery to shrink or slow the growth of the tumor. At times, it is used after surgery to help ensure that there are no cancer cells left in the body and to reduce the risk of recurrence.
Two chemotherapy medications that have been approved to treat liposarcoma are Halaven (eribulin) and Yondelis (trabedectin). These medications are intended for long-term use in patients with liposarcoma that is inoperable or has spread.

Radiation therapy is another treatment option for liposarcoma. This therapy involves targeting the tumor with high-energy beams that kill or slow the growth of cancer cells. It is mainly used before surgery to help shrink the tumor, making it easier to remove. But it may also be used after surgery to reduce the risk of recurrence.

Complementary and alternative medicine is not part of traditional medical care, and CAM is not a treatment for liposarcoma. But these therapies can be used along with traditional treatments. Some patients find they help cope with the stress and other psychological effects of navigating cancer treatment and in managing the side effects of chemotherapy and radiation.
CAM treatments include mind-body therapies, such as yoga, tai chi, acupuncture, massage therapy, meditation, and journaling, as well as homeopathic remedies like supplements. Before trying any CAM therapies, consult with your healthcare team. They can help confirm whether it will benefit your cancer treatment plan and, if so, they may be able to point you toward local groups or classes that are designed for cancer patients.
There are three main treatment options for liposarcoma. The first-line option is surgical removal, with the goal of removing all of the tumor as well as a small margin of healthy tissue surrounding the area. The other two options, chemotherapy and radiation, may be used before surgery to shrink or slow the growth of the tumor, or after surgery to reduce the risk of recurrence. Your healthcare team will work with you to determine the best course of treatment for your situation.

Going through cancer treatment is a challenging time. Navigating concerns about the body's ability to fight off cancer, getting to and from appointments, and experiencing the side effects of treatment are a lot to handle alone, so it's important to reach out to your friends and family for support before, during, and after treatment.
Depending on your treatment plan and recovery, you may need assistance with daily tasks. Be sure to plan ahead and don't hesitate to ask for help from your community. You may also want to find a support group online or in person, as it can be helpful to hear of others' experiences and get an idea of what to expect.
Remember you are not alone. If you need additional support mentally navigating your diagnosis and treatment, consider making an appointment with a licensed mental health professional. They can help you process your thoughts and give you tools to adjust to the changes.
Limiting processed foods and red meats can help ward off cancer risk. These recipes focus on antioxidant-rich foods to better protect you and your loved ones. Sign up and get your guide!
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Cleveland Clinic. Liposarcoma.
American Cancer Society. Benefits of good nutrition during cancer treatment.
Yamamoto N, Hayashi K, Tanzawa Y, et al. Treatment strategies for well-differentiated liposarcomas and therapeutic outcomesAnticancer Res. 2012;32(5):1821-1825.
Nassif NA, Tseng W, Borges C, Chen P, Eisenberg B. Recent advances in the management of liposarcomaF1000Res. 2016;5:2907. doi:10.12688/f1000research.10050.1
Longhi A, Setola E, Ferrari C, Carretta E. Complementary and alternative medicine in sarcoma patients treated in an Italian sarcoma center. J Cancer Res Ther. 2021 Apr-Jun;17(2):516-522. doi: 10.4103/jcrt.JCRT_348_20

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